Efficacy of the Emotion Awareness and Skills Enhancement (EASE) Program in Autism: A Randomized Controlled Trial.

This was a randomised controlled trial — people were assigned to treatments by chance, which is the most reliable way to tell whether a treatment itself caused a change.

It involved 109 people, a reasonably sized group for this kind of research.

The researchers concluded: "Findings suggest that EASE improves emotion dysregulation for autistic adolescents and young adults. PLAIN LANGUAGE SUMMARY: This study tested a mindfulness-based intervention to improve autistic adolescents' and young adults' ability to manage emotions."

This record does not state:

• how long the study ran

This is a plain-language summary of one paper's abstract, not medical advice. Talk to your child's clinician before changing anything.

Journal: Journal of the American Academy of Child and Adolescent Psychiatry

Year: 2026

Design: Randomized Controlled Trial

Participants: 109

Age range: 12-22 years

Intervention: emotion regulation

Co-occurring conditions: Affective Symptoms

Authors: Susan W White, Caitlin M Conner, Kelly Beck, Carla A Mazefsky

OBJECTIVE: Autistic adolescents and adults often struggle with emotion dysregulation, and advocates consistently encourage more research on mental health. This study aimed to establish efficacy for psychotherapeutic intervention for emotion dysregulation for autistic adolescents and young adults. METHOD: In this multisite randomized controlled trial, a primarily mindfulness-based intervention called the Emotion Awareness and Skills Enhancement (EASE) Program, developed to improve emotion dysregulation in autistic adolescents and young adults, was compared to a rigorous active control condition (ACC) that allowed for personalized and evidence-based intervention as long as it did not include EASE core elements. It was hypothesized that the EASE group would demonstrate a steeper decline in emotion dysregulation, as well as decreased mental health problems, compared to those in ACC. A total of 109 participants were randomized, 102 began treatment, 89 participants completed all treatment sessions. intent-to-treat (ITT; n = 109) analyses were conducted, with supplemental per protocol analyses (PP; n = 76). RESULTS: Primary outcomes included emotion dysregulation severity and its interference with daily functioning, whereas secondary outcomes assessed mental health symptoms. Condition-naive interviews, which gauged impairment related to dysregulation, showed that the EASE group had more treatment responders (63%) compared to ACC (44%) (p = .052, odds ratio = 2.85), but this difference was not statistically significant. EASE participants demonstrated greater declines in emotion dysregulation than those in ACC (Reactivity, b = -0.168, p = .017; Dysphoria, b = -0.182, p = .010) at endpoint. EASE participants demonstrated improvement in internalizing and externalizing symptoms, relative to baseline, based on self- and caregiver-report, whereas ACC participants showed improvement only in caregiver-reported externalizing symptoms. All effects were stronger in PP analyses, suggesting the possible importance of treatment dosage. CONCLUSION: Findings suggest that EASE improves emotion dysregulation for autistic adolescents and young adults. PLAIN LANGUAGE SUMMARY: This study tested a mindfulness-based intervention to improve autistic adolescents' and young adults' ability to manage emotions. Researchers compared the Emotion Awareness and Skills Enhancement (EASE) Program to an active control intervention in a multisite randomized controlled trial with 109 autistic participants (ages 12-22 years) whose caregivers reported the presence of emotion dysregulations at baseline. Those in EASE showed greater improvements in managing emotions compared to the control intervention. Both interventions were helpful with respect to mental health. EASE participants demonstrated improvements in both internalizing and externalizing symptoms, while the active control participants demonstrated improvements in externalizing symptoms only. These results suggest that EASE helps autistic youth and adults better manage their emotions. CLINICAL TRIAL REGISTRATION INFORMATION: Emotion Awareness and Skills Enhancement Program (EASE); https://clinicaltrials.gov/study/NCT03432832 DIVERSITY & INCLUSION STATEMENT: We worked to ensure that the study questionnaires were prepared in an inclusive way. We worked to ensure race, ethnic, and/or other types of diversity in the recruitment of human participants. One or more of the authors of this paper self-identifies as living with a disability.

Journal of the American Academy of Child and Adolescent Psychiatry, 2026

PMID 40750084

DOI 10.1016/j.jaac.2025.07.1058

This record was extracted from the paper's PubMed abstract and metadata. Full-text methods and risk-of-bias details were not reviewed.